Yi Zhang 张翼

Yi pioneered the work of magnetic digtial microfluidics (MDM) for point-of-care testing (POCT). This magnetic microfluidic manipulation technology overcomes the challenges associated with conventional continuous-flow microfluidic systems for sophisticated heterogeneous bioanalytical assays used in POCT. In MDM, droplets function as bioreaction chambers, and the fluidic operations are accomplished by transporting, merging, and splitting droplets with magnetic force through magnetic particles or other micro magnetic tools. MDM eliminates the need for complicated microfluidic components such as micro-pumps, -valves and interface connections, which makes MDM ideally suited for POCT.

张翼率先开展了磁性数字微流体应用于现场即时检测的研究工作。磁性数字微流体技术克服了传统连续微流控在进行多相生化分析中面临的挑战，因此更加适合现场即时检测。磁性数字微流体系统以液滴作为生化反应器，所有的流体操作通过使用磁粒子或者其他微型磁性工具控制液滴的移动、合并及分离来实现。磁性数字微流体完全避免了微流泵、阀及连结装置等微流组件，因此是适用于现场即时检测的理想平台。

Surface Energy Trap (SET) for MDM 表面能量陷阱

Droplets move freely on the low-energy surface of the MDM platform. High-energy regions could be patterned on the low-energy surface to anchor droplets, thereby facilitating droplet manipulation.

磁性数字微流体液滴在低能量表面运行，同时，可以在低能量表面上制造高能量表面能量陷阱，全部或部分锚定液滴，辅助液滴操作。

Modular MDM 模块化磁性数字微流体

Stacking flow circumvents the need for separate sample pre-treatments, such as filtration or centrifugation, which are often required prior to testing saliva samples using paper-based immunoassays.

堆叠侧向流能确保多样本同时在侧向流试纸上不分层，同时避免对唾液样本的前处理，可以一步实现唾液样本的快速检测。

A stacking flow immunoassay for the detection of dengue-specific immunoglobulins in salivary fluid, Lab Chip, 2015, 15, 1465

Directly interface microreaction tube and test strip for the detection of Salmonella in food with combined isothermal amplification and lateral flow assay, Food Microbiology, 107, 2022, 104062