Unconventional Microfluidics 非传统微流体

Magnetic Digital Microfluidics 磁性数字微流体

Yi pioneered the work of magnetic digtial microfluidics (MDM) for point-of-care testing (POCT). This magnetic microfluidic manipulation technology overcomes the challenges associated with conventional continuous-flow microfluidic systems for sophisticated heterogeneous bioanalytical assays used in POCT. In MDM, droplets function as bioreaction chambers, and the fluidic operations are accomplished by transporting, merging, and splitting droplets with magnetic force through magnetic particles or other micro magnetic tools. MDM eliminates the need for complicated microfluidic components such as micro-pumps, -valves and interface connections, which makes MDM ideally suited for POCT.


Surface Energy Trap (SET) for MDM 表面能量陷阱

Droplets move freely on the low-energy surface of the MDM platform. High-energy regions could be patterned on the low-energy surface to anchor droplets, thereby facilitating droplet manipulation.


Droplet transport, merging, mixing and particle extraction
Droplet dispensing
Droplet cross-platform transfer
Sample-to-Answer molecular diagnostics on the MDM Platform
 Advanced Materials2013, 25, 2903-2908

Modular MDM 模块化磁性数字微流体

ELISA on the 3D-Printed Modular MDM Platform
Carba NP phenotypical assay on the 3D-Printed Modular MDM Platform
在3D打印机的模块化磁性数字微流体平台上进行Carba NP反应
Microsystems & Nanoengineering, 2020, 6, 48

Paper-based Microfluidics 纸质微流体

Stacking flow circumvents the need for separate sample pre-treatments, such as filtration or centrifugation, which are often required prior to testing saliva samples using paper-based immunoassays.


A stacking flow immunoassay for the detection of dengue-specific immunoglobulins in salivary fluid, Lab Chip, 2015, 15, 1465

Directly interface microreaction tube and test strip for the detection of Salmonella in food with combined isothermal amplification and lateral flow assay, Food Microbiology, 107, 2022, 104062